An array of thiophene-based monomers has been synthesized, with tailormade side groups and energetics characteristics, enabling cell- and tissue integration and in vivo-polymerization using enzymatic-, electro- and photo-polymerization protocols. Polymerized structures forming electrodes, wires, and simple device architectures have successfully been achieved onto and into individual cells, nerves, the central nervous system (CNS), and around the heart of different animal models to form electrode functionality for stimulation and recording exhibiting minimal levels of invasiveness. Our findings open for a new pathway of electroceuticals targeting disorders and degenerative diseases that combine pharmaceutical functionality with bioelectronics which is amalgamated with cells, organs, and CNS.

I introduce flow zoometry, a whole-animal equivalent of flow cytometry, designed for large-scale, individual-level, high-content screening of animals. This approach addresses the fundamental bottlenecks in animal research: high costs, labor-intensive processes, time inefficiency, susceptibility to human error, and limited statistical significance. Flow zoometry marks a paradigm shift in high-throughput screening, extending the progression from molecules to cells and now from cells to entire animals.